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Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 2, 274-281, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

ATRIAL FIBRILLATION INDUCED BY INFUSION OF HYPERTONIC SOLUTIONS INTO THE CANINE SINUS NODE ARTERY IN SITU

SHIGETOSHI CHIBA 1, YASUYUKI SUZUKI 1, and KOROKU HASHIMOTO 1

1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan

Effects of hyperosmolality on sinoatrial activity were studied by the direct perfusion of hypertonic glucose or mannitol solution into the sinus node artery of dogs in which the vagus nerves were cut. High osmolality in plasma (over 600 mOsM) regularly caused atrial fibrillation after sinus bradycardia. The induction of fibrillation was not blocked by the administration of atropine or propranolol. However, atrial fibrillation was readily induced, not only by acetylcholine, but also by a catecholamine given during the infusion of a hypertonic solution. When the infusion of a hypertonic solution was continued, atrial fibrillation ceased spontaneously, and atrioventricular nodal rhythm took its place. Finally, an irreversible impairment resulted in cessation of sinus rhythm, even after infusion was interrupted, and reinfusion never again induced atrial fibrillation.

Submitted on December 18, 1968
Accepted on February 26, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.