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Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 2, 217-222, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC REMOVAL OF A 17agr-ETHYNYL GROUP FROM THE ANTIFERTILITY STEROID, NORETHINDRONE

KEITH H. PALMER 1, JANE F. FEIERABEND 1, BILLY BAGGETT 1, and M. E. WALL 1

1 Chemistry and Life Sciences Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina

The metabolic removal of the 17agr-ethynyl group from the antifertility steroid l7agr-ethynyl-17beta-hydroxy-estr-4-en-3-one to give estr-4-ene-3, 17-dione has been shown to occur when the former was incubated with a 10,000 x g supernatant from rabbit liver.

Submitted on October 17, 1968
Accepted on February 5, 1969






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.