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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHLORAZINE
*CHLORPROMAZINE
*DEXTROAMPHETAMINE
*LEVALLORPHAN
*MORPHINE
*NALORPHINE
*PENTAZOCINE
*PILOCARPINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 1, 9-13, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF ANALGESICS AND OTHER DRUGS ON MICE IN PHENYLQUINONE AND ROTAROD TESTS

JACK PEARL 1, HERBERT STANDER 1, and DONNA B. McKEAN 1

1 Department of Pharmacology, Sterling-Winthrop Research Institute, Rensselaer, New York

Fifteen minutes after s.c. injection, the narcotics (morphine and phenazocine) and the narcotic antagonists (nalorphine, levallorphan, l-cyclazocine and its cyclobutylmethyl homolog and l-pentazocine and its C-5 ethyl homolog) prevented phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Pilocarpine also did so but produced salivation at about the same doses that prevented phenylquinone-induced reactions. d-Pentazocine, chlorpromazine and d-amphetamine did not prevent phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Although the narcotic antagonists reached their peak activity in preventing phenylquinone-induced reactions within 15 min after injecton, the other drugs did not do so.

Submitted on July 19, 1968
Accepted on January 22, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.