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Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 1, 56-62, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

UPTAKE AND DISTRIBUTION OF SOME QUATERNARY AMMONIUM COMPOUNDS IN THE CENTRAL NERVOUS SYSTEM OF THE RAT

J. A. GOSLING 1 and T. C. LU 1

1 Department of Pharmacology, School of Medicine, University of California, Los Angeles, California

The uptake of a series of tritium-labeled methonium compounds in the central nervous system of adult Sprague-Dawley rats was investigated. Central nervous system tissue showed higher affinity for those methonium compounds with longer methylene chains. This differential drug uptake appeared to be unrelated to plasma radioactivity measured 4 hr after i.m. injections. Histologic localization of tritiated hexamethonium and decamethonium was undertaken using autoradiography. Radioactivity was associated with cells forming the choroid plexuses and the arachnoid (or "pia-arachnoid" in areas where histologic resolution was inconclusive). The remainder of the tissue sections appeared devoid of radioactivity. Possible routes of access of these drugs to cells of the choroid plexuses and arachnoid have been discussed, and the significance of the present findings to other in vivo and in vitro uptake studies has been noted.

Submitted on August 8, 1968
Accepted on December 17, 1968




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.