JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GUSSIN, R. Z.
Right arrow Articles by RONSBERG, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GUSSIN, R. Z.
Right arrow Articles by RONSBERG, M. A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 1, 194-206, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

CL 65,562 (4-(agr,agr,agr-TRIFLUORO-m-TOLUIDINO)-(NICOTINIC ACID), A NOVEL "HIGH CEILING" DIURETIC

R. Z. GUSSIN 1, J. R. CUMMINGS 1, E. H. STOKEY 1, and M. A. RONSBERG 1

1 Department of Experimental Pharmacology, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

CL 65,562 is a structurally novel and highly efficacious diuretic agent capable of promoting the excretion of as much as 30% of the sodium chloride filtered at the glomerulus. It is effective in all animal Species examined (rat, rabbit, guinea pig, dog and monkey) and by all common routes of administration. CL 65,562 is effective during both metabolic acidosis and alkalosis. CL 65,562 produces a diuresis similar in magnitude to that produced by furosemide and ethacrynic acid. The renal sites of action of CL 65,562 are interpreted to be the proximal tubule and the ascending limb of the loop of Henle, but an effect in the distal convoluted tubule has not been definitely excluded.

Submitted on September 19, 1968
Accepted on December 11, 1968






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.