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Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 2, 339-345, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

SUBCELLULAR LOCALIZATION OF MONOAMINE OXIDASE IN RAT TISSUES

JACQUES de CHAMPLAIN 1, ROBERT A. MUELLER 1, and JULIUS AXELROD 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

The subcellular localization of monoamine oxidase (MAO) was investigated by means of differential centrifugation and continuous sucrose gradients in the liver, heart, salivary gland and vas deferens of the rat. In the liver the MAO was mainly localized in the mitochondria paralleling the distribution of cytochrome oxidase. In the other tissues studied, a considerable amount of MAO activity could be detected in the microsomal fraction. In the heart the MAO was mainly localized in the microsomal fraction clearly dissociated from the distribution of the cytochrome oxidase. On continuous sucrose gradients the MAO-containing particles of the heart were closely associated with the norepinephrine storage vesicles. In the salivary gland denervation resulted in a partial disappearance of the MAO activity in all the subcellular fractions. In the vas deferens, although a considerable fraction of the MAO was present in the microsomes, this was less marked than in the heart and salivary gland. These studies suggest that the subcellular distribution of MAO is variable depending on the tissue and that in some organs MAO may be localized in the norepinephrine storage particles or in similar organelles.

Submitted on September 18, 1968
Accepted on December 11, 1968




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