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Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 2, 249-254, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

SUBSENSITIVITY OF THE RAT ILEUM TO CHOLINERGIC DRUGS

JOSEPH J. McPHILLIPS 1

1 Department of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia

Treatment of rats for 10 days with Di-Syston, an organophosphorus cholinesterase inhibitor, produced subsensitivity of the ileum to carbachol, oxotremorine and furtrethonium. The same treatment caused an increased sensitivity of the ileuin to acetylcholine and butyrylcholine which was not unexpected since both of these substances are hydrolyzed by ileum cholinesterase. Subsensitivity did not develop to the action of potassium or to the action of methacholine, a result which suggests that subsensitivity may develop only to certain types of drugs.

Submitted on September 18, 1968
Accepted on November 19, 1968




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L. Z. Bito, M. J. Dawson, and L. Petrinovi\l=c`\
Cholinergic Sensitivity: Normal Variability as a Function of Stimulus Background
Science, May 7, 1971; 172(3983): 583 - 585.
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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.