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*CHLORAZINE
*CHLORPROMAZINE
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Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 1, 63-67, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

CHLORPROMAZINE INHIBITION OF DEHYDRATION-INDUCED ANTIDIURESIS IN RATS

JOHN EDWARD MILMORE 1 and DAVID L. HAMMERMAN 1

1 Department of Biology, Long Island University, Brooklyn, New York

Chlorpromazine, administered to rats in doses of 2.5 to 20.0 mg/kg, was found to reverse the effects of 48 hr of water deprivation on the percentage of an acute water load excreted and on urine osmolality. These same doses had little or no effect upon the same parameters of kidney function in rats having free access to drinking water. Rats in which dehydration effects were blocked by chlorpromazine remained sensitive to exogenous antidiuretic hormone. The possible interference of chlorpromazine with the secretion of antidiuretic hormone is discussed.

Submitted on July 26, 1968
Accepted on October 31, 1968






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.