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Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 1, 146-150, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

ELECTROPHYSIOLOGIC EFFECTS OF LIDOCAINE IN AWAKE DOGS

TSUNEAKI SUGIMOTO 1, STEPHEN F. SCHAAL 1, NEIL M. DUNN 1, and ANDREW G. WALLACE 1

1 Department of Medicine, Duke University Medical Center, Durham, North Carolina

The purpose of these studies was to examine the actions of lidocaine on the electrophysiologic properties of the specialized conduction system in intact awake dogs. Recording and stimulating electrodes were placed over the sinoatrial node, bundle of His, right bundle branch and on the epicardial surface of the right atrium and ventricle. Lidocaine (1-4 mg/kg i.v.) failed to alter spontaneous heart rate or atrioventricular conduction time. Lidocaine prolonged conduction time in Purkinje tissue and total ventricular activation time only slightly. The drug had only a small effect on refractoriness of atrial and ventricular muscle but produced a substantial increase of diastolic thresholds. Lidocaine also produced a marked decrease of ventricular rate in dogs with heart block. The above actions of lidocaine were dose-dependent. The peak actions of lidocaine occurred 30 sec after injection and were largely dissipated by 10 min.

Submitted on August 19, 1968
Accepted on November 4, 1968




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R. Leor, B. Rabinowitz, H. Hod, and E. Kaplinsky
An Undocumented Effect of Lidocaine Revealed by Computerized Electrocardiography
Angiology, July 1, 1993; 44(7): 517 - 522.
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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.