JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HOLTZMAN, S. G.
Right arrow Articles by VILLARREAL, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOLTZMAN, S. G.
Right arrow Articles by VILLARREAL, J. E.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHLORAZINE
*CHLORPROMAZINE
*MORPHINE
*NALORPHINE
*PENTOBARBITAL
Medline Plus Health Information
*Drug Abuse
Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 1, 125-133, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

MORPHINE DEPENDENCE AND BODY TEMPERATURE IN RHESUS MONKEYS

STEPHEN G. HOLTZMAN 1 and JULIAN E. VILLARREAL 1

1 The University of Michigan, Department of Pharmacology, Ann Arbor, Michigan

Rectal temperature was recorded in monkeys restrained in primate chairs. Morphine dependence was produced by the s.c. administration of morphine (3.0 mg/kg) repeated every 6 hr. In nondependent monkeys, chair restraint produced a small fall in temperature (0.6 ± 0.1°C). In morphine-dependent monkeys placement in the restraining chair 3 to 7 hr after a regular injection of morphine precipitated falls in body temperature as large as 8°C. Body temperature returned to normal when morphine was administered. These hypothermic responses did not occur if the monkeys were placed in the restraining chair within the first 3 hr after morphine. Administration of 1.0 mg/kg of nalorphine to morphine-dependent monkeys, a dose which produced no change of body temperature in nondependent monkeys, precipitated a severe abstinence syndrome and a large hypothermia. This hypothermic effect of nalorphine could be demonstrated after only 1 week of morphine treatment. Nalorphine also produced hypothermia in ketobemidone-dependent monkeys.

Submitted on August 19, 1968
Accepted on October 28, 1968




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. H. Ko, M. F. Divin, H. Lee, J. H. Woods, and J. R. Traynor
Differential in Vivo Potencies of Naltrexone and 6beta-Naltrexol in the Monkey
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 772 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. A. Paronis and J. H. Woods
Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal,
J. Pharmacol. Exp. Ther., July 1, 1997; 282(1): 348 - 354.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.