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Journal of Pharmacology And Experimental Therapeutics, Vol. 166, Issue 1, 119-124, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

ALTERATIONS OF PINEAL GLAND BIORHYTHMS BY N-METHYL-3-PIPERIDYL BENZILATE (JB336)

JAMES H. MERRITT 1 and THOMAS S. SULKOWSKI 1

1 Pharmacology-Biochemistry Branch, Biosciences Division, United States Air Force School of Aerospace Medicine, Brooks Air Force Base, Texas

N-methyl-3-piperidyl benzilate (JB336), an anticholinergic psychotogenic agent, disrupts the circadian rhythm of serotonin in the rat pineal gland when the drug is administered at 0800 hours. The dose used, 1 mg/kg, has no effect on whole rat brain serotonin. JB336 alters hydroxyindole-O-methyltransferase activity at various times of the 24-hr day. Protein and total ribonucleic acid content of the rat pineal gland are found to have circadian rhythms. These rhythms are also disrupted by a single injection of 1 mg of JB336 per kg administered at 0800 hours.

Submitted on July 15, 1968
Accepted on October 29, 1968






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.