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Journal of Pharmacology And Experimental Therapeutics, Vol. 165, Issue 2, 289-293, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF YOHIMBINE ON TRYPTOPHAN METABOLISM

T. L. SOURKES 1, KRYSTYNA MISSALA 1, and BERTHA K. MADRAS 1

1 Laboratory of Chemical Neurobiology, Department of Psychiatry, McGill University, Montreal, Quebec, Canada

Yohimbine inhibits the oxidation of tryptophan in the rat. It interferes to a greater degree with the conversion of the pyrrole ring-2-C14 to respiratory C14O2, than with that of other labeled carbons tested in several radioisomers of tryptophan. It does not affect the oxidation of HC14OONa in vivo nor the action of Nacute-formylkynurenine in vitro. However, it inhibits tryptophan pyrrolase, apparently by hindering attachment of the hematin coenzyme to the apoenzyme.

Submitted on September 17, 1968
Accepted on October 29, 1968






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.