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*Compound via MeSH
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*CARBON DIOXIDE
*OXYGEN
*PENTAERYTHRITOL TETRANITRATE
Journal of Pharmacology And Experimental Therapeutics, Vol. 165, Issue 2, 274-285, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

BRONCHOPULMONARY EFFECTS OF PENTAERYTHRITYL TETRANITRATE AND ISOPROTERENOL

DOMINGO M. AVIADO 1, TAKETOSHI KISHIMOTO 1, and HENRY J. KNEIDINGER 1

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

The inhalation of pentaerythrityl tetranitrate (PETN) caused a significant reduction in pulmonary resistance in the anesthetized dog. The potency of PETN is one-third to one-fifth that of isoproterenol in producing an equivalent fall in pulmonary resistance. This effect of PETN was interpreted to indicate bronchodilatation and was accompanied by an inhibition of the cough reflex, fall in pulmonary arterial pressure, increase in pulmonary compliance and improvement in arterial blood oxygen tension. There were no significant changes in the heart rate and systemic blood pressure when minimal effective doses of PETN (11 to 112 , µg) were inhaled.

Submitted on June 19, 1968
Accepted on October 17, 1968






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