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Journal of Pharmacology And Experimental Therapeutics, Vol. 165, Issue 2, 190-195, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

ENZYMATIC CONVERSION OF NOREPINEPHRINE TO EPINEPHRINE BY THE BRAIN

LARISSA A. POHORECKY 1, MICHAEL ZIGMOND 1, HARVEY KARTEN 1, and RICHARD J. WURTMAN 1

1 Department of Nutrition and Food Science and Department of Psychology, Massachusetts Institute of Technology, Cambridge, Massachusetts

The epinephrine-forming enzyme phenylethanolamine-N-methyl transferase (PNMT) can be demonstrated in various brain regions of the rat, cat, hen and turtle. The activity of the enzyme is greatest when either norepinephrine or phenylethanolamine is used as its substrate in the olfactory tubercle and olfactory bulb. PNMT activity is elevated in the olfactory tubercle among rats treated with dexamethasone for 7 days. After the injection of H3-norepinephrine into the lateral cerebral ventricle, a large fraction of the amine is converted to H3-epinephrine and stored in the olfactory bulb.

Submitted on April 10, 1968
Accepted on October 14, 1968




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.