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Journal of Pharmacology And Experimental Therapeutics, Vol. 165, Issue 1, 60-70, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE SITE OF ACTION OF A NEW ANORECTIC AGENT, FENFLURAMINE

MARIANNE H. FOXWELL 1, WILLIAM H. FUNDERBURK 1, and JOHN W. WARD 1

1 A. H. Robins Research Laboratories, Richmond, Virginia

The effects of fenfluramine on the central nervous system of cats were studied and compared to those of d-amphetamine. Unlike d-amphetamine, fenfiuramine slowed cortical electrical waves, blocked cortical afterdiseharges and reduced the effects of stimulating the ascending activating system. Like d-amphetamine, fenfluramine reduced thalamic recruitment and increased the electrical activity in the ventromedial nucleus of the hypothalamus without modifying the activity of the lateral hypothalamus. It was concluded that the appetite-inhibiting action of fenfluramine, like that of d-amphetamine, is possibly due to stimulation of subcortical structures, probably the ventromedial nucleus of the hypothalamus.

Submitted on April 10, 1968
Accepted on September 26, 1968






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.