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Journal of Pharmacology And Experimental Therapeutics, Vol. 165, Issue 1, 102-107, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

INCREASED BIOSYNTHESIS OF CARDIAC NOREPINEPHRINE AFTER HYPOPHYSECTOMY

LEWIS LANDSBERG 1, JACQUES de CHAMPLAIN 1, and JULIUS AXELROD 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

The biosynthesis of norepinephrine in the hearts of chronically hypophysectomized rats has been studied by determining the rate of incorporation of labeled precursors into catecholamines. Both C14-tyrosine and H3-dopamine, administered as a single i.v. injection, were converted more rapidly to norepinephrine in the hearts of the hypophysectomized rats than in the controls. Previous work has indicated that hypophysectomy is associated with an increased turnover of cardiac norepinephrine. The present study demonstrates that increased de novo biosynthesis of catecholamines in the heart occurs concomitantly with the increased turnover. Small changes in the in vitro activities of the enzymes which metabolize catecholamines (monoamine oxidase and catechol-O-methyltransferase) in the hypophysectomized rat were also found.

Submitted on July 29, 1968
Accepted on September 17, 1968




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