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Journal of Pharmacology And Experimental Therapeutics, Vol. 164, Issue 2, 371-379, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

ANALGETIC ACTIVITY AND OTHER PHARMACOLOGIC PROPERTIES OF A STEROID; 17agr-ACETOXY-6-DIMETHYLAMINO-METHYL -21-FLTJORO-3-ETHOXYPREGNA-3, 5-DIEN-20-ONE HYDROCHLORIDE (SC-17599)

CHARLES R. CRAIG 1

1 Division of Biological Research, G. D. Searle and Company, Chicago, Illinois

This steroid was found to possees marked analgesic activity in several assays, being more potent than codeine or meperidine but less potent than morphine. High doses of the compound induce respiratory depression in the rabbit which can be counteracted by nalorphine. The analgetic effect of SC-17599, as measured by the rat tail-flick procedure, was not antagonized by nalorphine, while that of morphine was.

Submitted on July 14, 1966
Accepted on September 7, 1968




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I. J. McFadyen, H. Houshyar, L.-Y. Liu-Chen, J. H. Woods, and J. R. Traynor
The Steroid 17alpha -Acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3,5-dien-20-one (SC17599) Is a Selective {micro}-Opioid Agonist: Implications for the {micro}-Opioid Pharmacophore
Mol. Pharmacol., October 1, 2000; 58(4): 669 - 676.
[Abstract] [Full Text]


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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.