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Journal of Pharmacology And Experimental Therapeutics, Vol. 164, Issue 2, 302-311, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

MECHANISMS FOR THE BRONCHODILATOR EFFECTS OF CORTICOSTEROIDS IN THE SENSITIZED RABBIT

LUIS R. CARRILLO 1 and DOMINGO M. AVIADO 1

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

The bronchospasm accompanying anaphylaxis in the rabbit can be reduced by dexamethasone or hydrocortisone. There are two important mechanisms underlying this effect. The first is a depletion of histamine content in the lung after 1 week of daily administration of either corticosteroid. The second is a relaxation of the bronchial smooth muscle detected by a fall in pulmonary resistance immediately following an acute i.v. injection. These results can serve as the basis for developing new steroids with selective pulmonary actions.

Submitted on April 9, 1968
Accepted on August 22, 1968






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