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Journal of Pharmacology And Experimental Therapeutics, Vol. 164, Issue 1, 75-81, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

THE PREFERRED CONFORMATIONS OF EPHEDRINE ISOMERS AND THE NATURE OF THE ALPHA ADRENERGIC RECEPTOR

LEMONT B. KIER 1

1 Division of Biochemistry, Columbus Laboratories, Battelle Memorial institute, Columbus, Ohio

The preferred conformations of ephedrine and PSgr-ephedrine isomers have been deduced from molecular orbital calculations of total energy as a function of molecular geometry. A pattern of complementary features has been proposed which represents the alpha adrenergic receptor. The declining order of alpha adrenergic activity of the four isomers of ephedrine is explained satisfactorily by this proposed receptor model.

Submitted on February 22, 1968
Accepted on June 13, 1968






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.