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Journal of Pharmacology And Experimental Therapeutics, Vol. 164, Issue 1, 185-190, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF CHRONIC CORD TRANSECTION ON THE EFFECTS OF 5-HYDROXYTRYPTOPHAN, l-TRYPTOPHAN AND PARGYLINE ON SPINAL NEURONAL ACTIVITY

TAKESHI SHIBUYA 1 and EDMUND G. ANDERSON 1

1 Department of Pharmacology, University of Illinois, College of Medicine, Chicago, Illinois

Current evidence suggests that the 5-hydroxytryptamine (5-HT) present in the spinal cord is localized in the terminals of bulbospinal neurons and that the actions of 5-hydroxytryptophan (5-HTP), l-tryptophan and pargyline on spinal neuronal activity result from intraneuronal accumulations of 5-HT which overflows to activate receptors. If these postulates are correct, spinal cord 5-HT and the actions of 5-HTP, l-tryptophan and pargyline should be markedly diminished following section of the bulbospinal neurons. Assay of the lumbosacral cord of cats 3 weeks after a midthoracic cord transection revealed 5-HT values which were only 25% of the nontransected controls. Pargyline and l-tryptophan were without effect on the spinal reflexes in cats with chronic cord transection. These observations support the above conclusions. However, in chronic spinal cats 5-HTP still increased the monosynaptic spike height and depressed polysynaptic and dorsal root reflexes. Since the actions of 5-HTP were prevented by pretreatment with a decarboxylase inhibitor and reversed by a 5-HT antagonist, the actions of 5-HTP seem to be mediated by 5-HT. It thus appears that 5-HTP can be converted to 5-HT at sites other than descending bulbospinal neurons.

Submitted on February 14, 1968
Accepted on July 8, 1968




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.