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Journal of Pharmacology And Experimental Therapeutics, Vol. 163, Issue 2, 287-289, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

ATROPINE EXCITATION OF ESOPHAGEAL SMOOTH MUSCLE

J. CHRISTENSEN 1 and G. F. LUND 1

1 Gastroenterology Research Laboratory, Department of Internal Medicine, The University of Iowa, Iowa City, Iowa

Very large concentrations of atropine sulfate, but not atropine methyl bromide, excite powerful rhythmic contractions of esophageal circular smooth muscle from the opossum. The response is dose-related, reversible by washing and not subject to tachyphylaxis and persists during a long period of exposure. Mean geometric threshold concentration for l-hyoscyamine, 4.59 x 10-5 g/ml (as the base), is significantly lower than that for racemic atropine sulfate, 3.22 x 10-4 g/ml (as the base). The response to atropine is not affected by nicotine, hexamethonium, tolazoline, dehydroergotamine, propranolol, d-tubocurarine, tripelennamine, methysergide and tetrodotoxin, or by local anesthetics except at very high concentrations. It persists during histamine tachyphylaxis. The results indicate that the esophageal response reflects a direct action of atropine on muscle.

Submitted on April 24, 1968
Accepted on June 3, 1968




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.