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Journal of Pharmacology And Experimental Therapeutics, Vol. 163, Issue 1, 216-221, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

MECHANISM OF MONOMETHYLHYDRAZINE EXCRETION BY THE MAMMALIAN KIDNEY

FREDRIC L. COE 1, ROBERT W. HOWE 1, and JAMES A. GOETTING 1

1 Pharmacology-Biochemastry Branch, Biosciences Division, USAF SChool of Aerospace Medicine, Brooks Air Force Base, Texas

Renal pathways for excretion of monomethylhydrazine (MMH) have been studied by standard clearance methods. The renal handling of this substance is quite similar to that of hydrazine, its parent base. MMH is excreted by a combination of glomerular ifitration, passive diffusion-mediated reabsorption and simultaneous tubular secretion. The secretion process has a limited capacity for MMH transfer and can be inhibited by 2, 4-dinitrophenol. The percentage of the filtered load of MMH excreted is influenced by urine pH. It approximates 100% below pH 6.5 and falls to 20% above pH 7.

Submitted on June 26, 1967
Accepted on April 8, 1968






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.