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Journal of Pharmacology And Experimental Therapeutics, Vol. 163, Issue 1, 210-215, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

THE DIURETIC ACTIVITY OF ETHACRYNIC ACID IN RATS

G. R. ZINS 1, R. A. WALK 1, R. Z. GUSSIN 1, and C. R. ROSS 1

1 Pharmacology Research Laboratories, The Upjohn Company, Kalamazoo, Michigan; Department of Pharmacology, State University of New York Upstate Medical Center, Syracuse, New York

Intravenous administration of large doses of ethacrynic acid to rats enhanced the excretion of sodium, potassium and chloride in the urine. Single doses of 37.5 and 125 mg/kg increased water and potassium excretion 2-fold, sodium excretion 3-fold and chloride excretion 4-fold in relation to parallel control animals. Single dose activity was confined to the 1st hr after injection whereas effects persisted for the duration of observation when animals were primed with 25 mg/kg and sustained with 50 mg/kg/hr. In no instance was toxicity apparent inthese studies. Thus, ethacrynic acid shares with organomercurial diuretics and the cardiac glycosides the characteristic of being less efficient but certainly not incapable of exerting its pharmacologic actions in the rat.

Submitted on March 28, 1968
Accepted on April 26, 1968




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.