CHANGES IN RENAL AND PLASMA LIPID CONTENT IN CATS AFTER CARBON TETRACHLORIDE

¹ Department of Pharmacology, School of Medicine and Dentistry, The University of Rochester, Rochester, New York

Cats inhaling CCLl₄ (10,000 ppm) exhibited a significant fall in both plasma and renal total lipid contents 24 hr after termination of a 4-hr exposure. Plasma phospholipids decreased within 30 min and returned to normal in 1 hr; 24 hr later, levels were again depressed. Plasma free fatty acids were not elevated until 24 hr after CCl₄ exposure; plasma triglyceride concentrations were unchanged. Renal cortical phospholids increased within 30 min during CCl₄ inhalation; free fatty acid levels rose within 60 min; triglyceride concentrations decreased during the first 30 min, were elevated at 60 min and fell again 24 hr after a 4-hr CCl₄ exposure. Carbon tetrachloride induced hyperglycemia in cats within 2 min after the start of inhalation; maximal increases in blood glucose occurred at the end of a 120-min inhalation period, and high levels were maintained 120 min after the withdrawal of CCl₄. Both plasma and adrenal catecholamine levels were unchanged in cats breathing CCl₄ for 60 min.