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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHLORDANE
*DDT
*PHENOBARBITAL
*WARFARIN
Journal of Pharmacology And Experimental Therapeutics, Vol. 162, Issue 2, 338-343, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

STIMULATORY EFFECT OF PHENOBARBITAL AND INSECTICIDES ON WARFARIN METABOLISM IN THE RAT

MASAYUKI IKEDA 1, A. H. CONNEY 1, and J. J. BURNS 1

1 The Wellcome Research Laboratories, Burroughs Wellcome & Co. (U.S.A.) Inc., Tuckahoe, New York; Albert Einstein College of Medicine, New York, New York

Treatment of rats with phenobarbital, chlordane or DDT stimulates the activity of hepatic enzymes that hydroxylate warfarin in positions 6, 7 and 8. This effect is paralleled by enhanced hydroxylation of warfarin in vivo in pretreated rats and by a decreased acute toxicity of warfarin. The stimulatory effect of phenobarbital on warfarin metabolism in the rat offers an explanation for the observations of others indicating that phenobarbital decreases the anticoagulant action of warfarin in man.

Submitted on December 27, 1967
Accepted on April 1, 1968




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.