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Journal of Pharmacology And Experimental Therapeutics, Vol. 162, Issue 2, 331-337, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

DIURETIC EFFECT OF CHRONIC MORPHINE TREATMENT IN RATS

CLAUDE MARCHAND 1 and GUSTAVE DENIS 1

1 Departments of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, P.Q., Canada

The effect of chronic morphine treatment on urine formation was studied in rats. In contrast to its acute antidiuretic effect, chronic administration of morphine caused an increase in urinary volume, with an augmentation of solute excretion. This solute diuresis was due, in part, to increased urinary sodium, potassium, phosphate and calcium, but the augmentation of urea excretion was mainly responsible. The increase in urinary volume was partially blocked by nalorphine, with similar antagonistic effects on calcium and urea excretion. These observations may serve to explain the tolerance to the antidiuretic effect of morphine.

Submitted on February 22, 1968
Accepted on March 28, 1968






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