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Journal of Pharmacology And Experimental Therapeutics, Vol. 162, Issue 2, 309-318, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF A CHOLINESTERASE INHIBITOR WHEN INJECTED INTO THE MEDULLA OF THE RABBIT

WILLIAM C. STEWART 1 and ESSIE A. ANDERSON 1

1 Physiology Section, Defence Research Establishment Suffield, Ralston, Alberta, Canada

Microinjections of the cholinesterase inhibitor sarin were used to explore the pons and medulla of the rabbit. Bilateral injections into the lateral reticular nucleus of the medulla at the level of the inferior fovea caused respiratory arrest. Respiration was quickly restored after atropine was given i.v. Other effects observed, and reversed by i.v. atropine, included acceleration of respiratory rate, bradycardia and hypotension. The results are interpreted as indicating the location of a nervous center concerned with the control of the respiratory muscles, which is the site of the central respiratory paralysis in systemic sarin poisoning.

Submitted on June 10, 1966
Accepted on March 29, 1968




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