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Journal of Pharmacology And Experimental Therapeutics, Vol. 161, Issue 2, 382-388, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

ALTERATION IN BILIARY BILIRUBIN CONTENT AND NONERYTHROPOIETICALLY DERIVED BILIRUBIN SYNTHESIS IN RATS AFTER agr-NAPHTHYLISOTHIOCYANATE ADMINISTRATION

Robert J. Roberts 1 and Gabriel L. Plaa 1

1 Oakdale Toxicology Center, Deportment of Pharmacology, College of Medicine, The University of Iowa, Iowa City, Iowa

agr-Naphthylisothiocyanate (ANIT) significantly enhanced the biliary bilirubin content as early as 2 hr after administration. The temporal aspects of this effect coincide with the development of hyperbilirubinemia after ANIT administration. The enhanced excretion of bilirubin is accompanied by an increase in the percentage incorporation of dgr-aminolevulinic acid-14C into bilirubin, suggesting that one source of the ANIT-induced increase in bilirubin excretion may be nonerythropoietic in nature. Both the increase in bilirubin excretion and the incorporation of 14C into bilirubin are dose- and time-dependent.

Submitted on December 11, 1967
Accepted on February 2, 1968






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.