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Journal of Pharmacology And Experimental Therapeutics, Vol. 161, Issue 2, 197-204, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

PREVENTION OF PULMONARY EMPHYSEMA IN RATS BY PROGESTERONE

Haruo Ito 1 and Domingo M. Aviado 1

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Pulmonary emphysema was induced experimentally by tracheal ligation and intratracheal injection of phytohemagglutinin. The functional consequences consisted of elevated functional residual capacity, increase in pulmonary resistance and impaired minute volume response to inhalation of low oxygen mixture. Daily injections of progesterone for 7 weeks prevented the appearance of experimental emphysema.

Submitted on December 6, 1967
Accepted on February 22, 1968






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.