THE EFFECTS OF BRADYKININ ON THE PULMONARY VEINS

¹ Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana

The intravenous infusion of bradykinin into a group of dogs with intact pulmonary circulation caused a transient increase in pulmonary arterial pressure and cardiac output, but caused a sustained increase in pressure in the small pulmonary vein. In another group of intact dogs, the left lower lobe was separately perfused with systemic arterial blood at a constant rate of flow. In this group, observations on the active vascular effect were obtained from the separated lobe, whereas observations on the passive vascular effects were obtained from normally perfused lobes. These data indicate that bradykinin causes active constriction of pulmonary veins and suggest that vessels upstream to the veins, presumably the arteries, are passively distended. The passive vascular effects caused by the increase in cardiac output modify the active effects of bradykinin on the pulmonary vessels.

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