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Journal of Pharmacology And Experimental Therapeutics, Vol. 161, Issue 1, 183-190, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HYDRAZINE UPON RENAL EXCRETION OF SODIUM, POTASSIUM AND WATER

Fredric L. Coe 1 and Patricia R. Korty 1

1 Physiological Chemistry Section, Biosciences Branch, USAF School of Aerospace Medicine, Brooks Air Force Base, Texas

Hydrazine a weakly basic amine chemically related to ammonia, is a diuretic agent that increases renal excretion of sodium, potassium and water when given i.v. to dogs. Increased excretion of sodium is due to a fall in net tubular reabsorption, whereas increased potassium excretion may result from a combination of augmented delivery of sodium to the distal tubule and direct stimulation of potassium secretion. Selective infusion of hydrazine into one renal artery results in an ipsilateral diuresis of sodium and water, indicating that these effects reflect a direct renal action.

Submitted on June 22, 1967
Accepted on January 9, 1968






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.