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*FORMALDEHYDE
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Journal of Pharmacology And Experimental Therapeutics, Vol. 160, Issue 1, 243-248, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE ACUTE INFLAMMATORY RESPONSE. II. INFLUENCE OF ANTIHISTAMINICS AND CATECHOLAMINES ON FORMALDEHYDE-INDUCED EDEMA

J. H. Brown 1, H. K. MacKey 1, D. A. Riggilo 1, and N. L. Schwartz 1

1 Mead Johnson Research Center, Evansville, Indiana

Antihistamines, in general, inhibit the formaldehyde-induced inflammatory response in the hind paws of rats. This inhibition is not antagonized by sotalol (MJ 1999), a beta adrenergic blocking agent. Catecholamines, which also inhibit the inflammatory response, are blocked by sotalol in this regard. Antiinflammatory activity of the antihistamines does not correlate well with antihistaminic activity per se, antiserotonin activity or local anesthetic activity, thus suggesting a nonspecific mode of action for these drugs. Possible mechanisms of action are discussed.

Submitted on October 3, 1967
Accepted on November 17, 1967




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.