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Journal of Pharmacology And Experimental Therapeutics, Vol. 160, Issue 1, 212-216, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF HYDRAZINE UPON THE CONCENTRATIONS OF FREE AMINO ACIDS OF PLASMA AND URINE

Patricia Korty 1 and Fredric L. Coe 1

1 Physiological Chemistry Section, Biosciences Branch, United States Air Force School of Aerospace Medicine, Brooks Air Force Base, Texas

The effects of hydrazine on free amino acids of plasma and urine were studied in dogs. Administration of hydrazine in doses of 25 mg/kg produces large increases in the plasma concentration of all amino acids, with a concomitant rise in urinary excretion. Tyrosine and alanine are particularly responsive to hydrazine, manifesting 22- and 4-fold increases, respectively. The mechanisms responsible for these effects of hydrazine are unknown; however, some data implicate impairment of gluconeogenesis.

Submitted on May 29, 1967
Accepted on October 17, 1967






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