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Journal of Pharmacology And Experimental Therapeutics, Vol. 160, Issue 1, 189-200, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE TERATOGENIC ACTIVITY OF THALIDOMIDE IN RABBITS AND RATS

Herbert Schumacher 1, David A. Blake 1, Joan M. Gurian 1, and James R. Gillette 1

1 Laboratory of Chemical Pharmacology and Biometrics Research Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The teratogenic potency of thalidomide has been compared in rabbits and rats. After p.o. administration in daily doses ranging from 25 to 200 mg/kg, thalidomide was markedly teratogenic in rabbits but only slightly so in rats. After i.v. injection of the drug dissolved in dimethyl sulfoxide or propylene glycol, teratogenic effects were observed both in rabbits receiving daily doses as low as 2.5 to 10 mg/kg and in rats receiving doses of 10 mg/kg. Thus, after i.v. injection, thalidomide is only 2 to 4 times as potent in rabbits as in rats.

Submitted on June 21, 1967
Accepted on October 25, 1967




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