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Journal of Pharmacology And Experimental Therapeutics, Vol. 16, Issue 6, 435-448, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

ON THE ABSORPTION OF LOCAL ANESTHETICS THROUGH THE GENITO-URINARY ORGANS

DAVID I. MACHT 1

1 From the Pharmacological Laboratory of the Johns Hopkins University and the James Buchanan Brady Urological Institute, Baltimore

1. The local anesthetics, cocain, alypin and apothesin, were studied in regard to their penetration through and absorption from various genito-urinary organs.

2. It was found that these drugs are more or less readily absorbed through the urethra, ureters, pelvis of the kidney, praeputium and vagina.

3. It was found that while the local anesthetics are readily and rapidly absorbed from the urethra, they are very poorly absorbed from the urinary bladder.

Submitted on September 8, 1920






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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.