STUDIES OF CHRONIC INTOXICATIONS ON ALBINO RATS I. ORGANIZATION OF THE INVESTIGATIONS

¹ From the Department of Pharmacology of the Medical School of Western Reserve University, Cleveland

Under the organization adopted, the growth of control rats differs from the "standard growth curve" by a range of –1 to + 1.8 per cent per week, with a median difference of +0.13 per cent. Female rats show less variation than male rats.

Standards of food-consumption were determined; such that the extremes of control experiments differ from the standard by a range of 0.01 to 1.4 gram per rat per day, or –0.08 to +19 per cent; with a mean of +0.8 gram, or +7 per cent.

The departures from the standard curves are generally parallel for food and growth; but they are not strictly proportional.

Experiments results may be considered abnormal if . The growth differs from the standard by more that –1 and +1.8 per cent per week.

b. The food differs from the standard by more than –0.01 and 1.5 gram per rat per day; or by more than –0.08 and +19 per cent.

c. The growth and food depart from the standard in contrary directions.

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