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Journal of Pharmacology And Experimental Therapeutics, Vol. 16, Issue 2, 71-a-107, 1920
Copyright © 1920 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF DRUGS ON THE OUTPUT OF EPINEPHRIN FROM THE ADRENALS VI. ATROPINE; PILOCARPINE

G. N. STEWART 1 and J. M. ROGOFF 1

1 From the H. K. Cushing Laboratory of Experimental Medicine, Western Reserve University

1. The rate of output of epinephrin from the adrenals (in cats) is not materially influenced by the action of atropine or pilocarpine. A moderate increase in the rate of liberation may be produced by atropine, which in large doses may be preceded by a moderate transient depression of the rate of output. The augmentation of the output, if any is caused, by pilocarpine is small and is not comparable with the large increase in the rate of epinephrin liberation caused by strychnine or the immediate effect of nicotine.

2. One experiment was performed which indicates that pilocarpine is capable of producing a moderate depletion of the epinephrin store, in adrenal glands with intact nerve supply.

Submitted on June 28, 1920






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Copyright © 1920 by the American Society for Pharmacology and Experimental Therapeutics.