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Journal of Pharmacology And Experimental Therapeutics, Vol. 16, Issue 1, 61-69, 1920
Copyright © 1920 by American Society for Pharmacology and Experimental Therapeutics

THE STABILITY OF BENZYL ALCOHOL SOLUTIONS

DAVID I. MACHT 1 and ALFRED T. SHOHL 1

1 From the Pharmacological Laboratory of the Johns Hopkins University and the James Buchanan Brady Urological Institute, Baltimore, Maryland

1. Various specimens of benzyl alcohol solutions were sealed in ampoules made of different kinds of glass, and such solutions were examined at intervals of time in regard to their anesthetic efficiency on the one hand, and their hydrogen-ion concentration on the other.

2. Solutions of benzyl alcohol kept in non-soluble glass preserve their anesthetic properties completely for long periods of time and such solutions tend to increase their hydrogen-ion concentration very slowly.

3. Benzyl alcohol solutions kept in soft glass or alkaline containers tend to become alkaline in reaction and rapidly deteriorate in their anesthetic efficiency.

4. It is suggested that the best method of preserving benzyl alcohol solutions is to prepare such solutions from a benzyl alcohol free from benzaldehyde, and to seal the same after the addition of a buffer solution in hard glass ampoules.

Submitted on June 12, 1920






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Copyright © 1920 by the American Society for Pharmacology and Experimental Therapeutics.