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Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 2, 372-378, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF DIETHYLPROPION-1-C14 HYDROCHLORIDE BY THE HUMAN

E. C. Schreiber 1, B. H. Min 1, A. V. Zeiger 1, and J. F. Lang 1

1 The Wm. S. Merrell Company, Division of Richardson-Merrell Inc., Cincinnati, Ohio

Diethylpropion undergoes extensive metabolism in the human. Ether extracts of acidified and alkalinized urine, before and after hydrolysis, were examined by thin-layer chromatography. Relative amounts of C14-labeled metabolites were quantitatively determined from peak area measurements on radioactive chromatogram scans. In addition, an isotope dilution technique was used for the determination of hippuric and mandelic acids. Twenty-one metabolic products were identified; two major basic metabolites remain unidentified. The metabolite present in the greatest quantity, hippuric acid, represented about 27% of the radioactivity excreted in the urine between 8 and 12 hr after ingestion of drug.

Submitted on February 2, 1967
Accepted on October 30, 1967






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.