JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bloom, F. E.
Right arrow Articles by Aghajanian, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bloom, F. E.
Right arrow Articles by Aghajanian, G. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 2, 261-273, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

AN ELECTRON MICROSCOPIC ANALYSIS OF LARGE GRANULAR SYNAPTIC VESICLES OF THE BRAIN IN RELATION TO MONOAMINE CONTENT

Floyd E. Bloom 1 and George K. Aghajanian 1

1 Departments of Anatomy, Pharmacology and Psychiatry, Yale University School of Medicine and the Connecticut Mental Health Center, New Haven, Connecticut

The incidence of nerve endings exhibiting large (800-1200 Å) granular vesicles was quantified for several regions of the rat brain, and the values were compared to the reported regional brain content of catecholamines and serotonin by biochemical and fluorescence histochemical measurements. A correlation was found between the total percentage of large vesicle-containing nerve endings and the combined content of norepinephrine and serotonin; high dopamine content did not correlate with the incidence of the large granular vesicles. The fine structural appearance of the granular vesicles was also analyzed after treatments producing lowered (reserpine, agr-methyl-m-tyrosine, agr-methyltyrosine, p-Cl-phenylalanine) or elevated (pargyline, intraventricular norepinephrine) brain monoamine content. In each case the electron opacity of the contents of the granular vesicles was estimated with respect to standard reference criteria. No drug was found to produce changes in vesicle electron opacity which agreed in magnitude with the expected change in amine levels. The large granular vesicles may represent proteinladen organelles found commonly in norepinephrine- and serotonin-containing neurons. The biologic function of these cellular inclusions remains to be elucidated.

Submitted on August 2, 1967
Accepted on September 26, 1967




This article has been cited by other articles:


Home page
 FASEB J.Home page
Z. Chiti and A. G. Teschemacher
Exocytosis of norepinephrine at axon varicosities and neuronal cell bodies in the rat brain
FASEB J, August 1, 2007; 21(10): 2540 - 2550.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
F. E. Bloom, S. Algeri, A. Groppetti, A. Revuelta, and E. Costa
Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure
Science, December 5, 1969; 166(3910): 1284 - 1286.
[Abstract] [PDF]

Home page
 ScienceHome page
G. R. Siggins, B. J. Hoffer, and F. E. Bloom
Cyclic Adenosine Monophosphate: Possible Mediator for Norepinephrine Effects on Cerebellar Purkinje Cells
Science, September 5, 1969; 165(3897): 1018 - 1020.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.