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Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 1, 91-97, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

DIFFERENTIAL EFFECTS OF CALCIUM REMOVAL UPON VASCULAR SMOOTH MUSCLE CONTRACTION INDUCED BY NOREPINEPHRINE, HISTAMINE AND POTASSIUM

Patricia M. Hudgins 1 and George B. Weiss 1

1 Department of Pharmacology, Medical College of Virginia, Richmond, Virginia

The manner in which norepinephrine, histamine and potassium depend upon calcium ion to elicit contractile responses in aortic strips has been investigated using mammalian Ringer's solutions containing 1.5 mM Ca (normal Ringer's), no added Ca and no added Ca with 0.1 mM ethylenediamine tetraacetate (EDTA). In Ringer's solution with no added Ca the tension induced by potassium (25 mM), histamine (1 µg/ml) and norepinephrine (0.1 µg/ml) is, respectively, 22, 60 and 78% of that obtained in normal Ringer's. Exposure to Ringer's solution with no added Ca but with EDTA further reduces responses to potassium (to 4% of control value), to histamine (to 5%) and to norepinephrine (to 28%). The response to norepinephrine but not that to potassium is inhibited by procaine. The rate of efflux of Ca45 into Ringer's solution with no added Ca but with EDTA is decreased by addition of norepinephrine, and this effect is also antagonized by procaine. It appears that both norepinephrine and procaine are able to affect firmly bound calcium stores which are not acted upon by potassium or by histamine. In aortic strips, the mechanisms by which potassium, histamine and norepinephrine interact with calcium to induce contraction are different.

Submitted on July 3, 1967
Accepted on September 11, 1967




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