![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
1 Department of Pharmacology, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota
The times of appearance and concentrations of dopa (DA), dopamine, norepinephrine and epinephrine were determined in the embryo and in the heart of the embryonic and developing chick. DA and dopamine were first detected in the heart on the 4th and 6th days of incubation, respectively. Cardiac norepinephrine and epinephrine were first detected on the 3rd day of incubation. The endogenous levels of these catecholamines and DA in the heart fluctuated throughout embryonic development and for a short time after hatching. During the remainder of development there were no further marked changes in their concentrations. In the whole embryo, DA and dopamine were first detected on the 1st and 2nd days, respectively. Norepinephrine and epinephrine were first detected on the 3rd day. As there appeared to be a somewhat orderly sequential appearance of these catechols, in the whole embryo, in accordance with the scheme for their biosynthesis, the order of appearance of each of the enzymes responsible for their synthesis was determined. Tyrosine hydroxylase, dopa decarboxylase, dopamine 
-oxidase and phenylethanolamine-N-methyl transferase activities were first detected on the 1st, 2nd, 4th and 6th days of incubation, respectively.
This article has been cited by other articles:
|
|
 |
|
  S. N. Ebert and D. G. Taylor Catecholamines and development of cardiac pacemaking: An intrinsically intimate relationship Cardiovasc Res, December 1, 2006; 72(3): 364 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dragon and R. Baumann Hypoxia, Hormones, and Red Blood Cell Function in Chick Embryos Physiology, April 1, 2003; 18(2): 77 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Ebert and R. P. Thompson Embryonic Epinephrine Synthesis in the Rat Heart Before Innervation : Association With Pacemaking and Conduction Tissue Development Circ. Res., January 19, 2001; 88(1): 117 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fritsche, T. Schwerte, and B. Pelster Nitric oxide and vascular reactivity in developing zebrafish, Danio rerio Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2200 - R2207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Bilodeau, T. Boulineau, R. L. Hullinger, and O. M. Andrisani Cyclic AMP Signaling Functions as a Bimodal Switch in Sympathoadrenal Cell Development in Cultured Primary Neural Crest Cells Mol. Cell. Biol., May 1, 2000; 20(9): 3004 - 3014. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Baumann, C. Blass, R. Gotz, and S. Dragon Ontogeny of Catecholamine and Adenosine Receptor-Mediated cAMP Signaling of Embryonic Red Blood Cells: Role of cGMP-Inhibited Phosphodiesterase 3 and Hemoglobin Blood, December 15, 1999; 94(12): 4314 - 4320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dragon, N. Offenhauser, and R. Baumann cAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1219 - R1226. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
