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Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 1, 236-242, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

A TECHNIQUE FOR ACCURATE MEASUREMENT OF MODERATE DEGREES OF ALCOHOL INTOXICATION IN SMALL ANIMALS

R. J. Gibbins 1, H. Kalant 1, and A. E. Le Blanc 1

1 Addiction Research Foundation of Ontario and Department of Pharmacology, University of Toronto, Toronto, Canada

An instrument is described with which it is possible to differentiate the degrees of intoxication produced in rats by four doses of ethanol between 1.6 and 2.5 g/kg. The apparatus consists of a nylon belt moving continuously over an electrified grid. If the test animal fails to walk the belt in treadmill fashion, it is forced on to the grid, receiving a shock and activating a timer. The total time off the belt during the trial is linearly related to the blood ethanol level in the range of 150 to 300 mg/100 ml. Minimal training of the subject is required, and subsequent practice effect is negligible.

Submitted on May 15, 1967
Accepted on August 22, 1967




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.