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Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 1, 229-235, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE HYPERGLYCEMIC EFFECTS OF NONTHIAZIDE DIURETICS

John K. Wales 1, Alison Grant 1, and Frederick W. Wolff 1

1 The Research Foundation of the Washington Hospital Center and Department of Medicine, George Washington University, Washington, D.C.

The nonthiazide diuretics, furosemide, ethacrynic acid, chlorthalidone, Bayer 1500 and triamterene, which act as diuretics in man, have been shown to be hyperglycemic in rats. There is no correlation with diuretic activity at comparable dosages. Ex 4877, an experimental compound which antagonizes the saluretic effect of thiazides, is also hyperglycemic. Other reports of the hyperglycemic effects of these drugs are discussed. It is suggested that the etiology of the hyperglycemia from these drugs is not related to their renal activity and may be multifactorial.

Submitted on April 7, 1967
Accepted on September 13, 1967






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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics.