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Journal of Pharmacology And Experimental Therapeutics, Vol. 159, Issue 1, 18-21, 1968
Copyright © 1968 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF EXOGENOUS DOPAMINE ON RAT ADRENAL ASCORBIC ACID

A. B. King 1 and J. A. Thomas 1

1 Department of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia

Corticotrophin activity, as reflected by adrenal ascorbic acid depletion, was enhanced after the injection of varying amounts of dopamine. Exogenous dopamine was effective in doses of 0.1 mg/kg. The action of dopamine, unlike that of epinephrine, was not blocked by phenoxybenzamine. The combination of morphine and pentobarbital abolished the effect of dopamine, suggesting that its action was mediated through neural channels. It appears that dopamine may be acting as a neurotransmitter in the regulation of corticotrophin secretion.

Submitted on May 19, 1967
Accepted on August 22, 1967






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