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1 Department of Pharmacology, The University of Vermont College of Medicine, Burlington, Vermont
In spinal cats, cardioacceleration was elicited by close i.a. injections of angiotensin toward either the right or the left stellate and middle cervical ganglia. The response resulted primarily from stimulation of the stellate ganglion, since it was reduced or abolished when this ganglion was removed. The response in no way involved the middle cervical ganglion because it was unaffected by removing this ganglion. In most cats the threshold dose for angiotensin varied from 0.03 to 0.1 µg/kg and the response latency varied from 10 to 20 sec. The ganglionic receptors for angiotensin differ from those for acetylcholine, since the positive chronotropic response to the peptide was unaltered when ganglionic transmission had been blocked with hexamethonium and atropine. In those experiments in which removing the stellate ganglion reduced but did not abolish the positive chronotropic effect of i.a. angiotensin, the residual response was always delayed in onset. This ancillary cardioaccelerator effect was due to catecholamines released from the adrenal medulla by recirculating angiotensin, since it was abolished after bilateral adrenalectomy. No evidence was found for a direct effect of angiotensin on the sinoatrial node or sympathetic nerve endings in the heart.
Submitted on August 15, 1967
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