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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 3, 504-509, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

CARDIOVASCULAR ACTIONS OF IPROVERATRIL

Gordon Ross 1 and Charles R. Jorgensen 1

1 Departments of Physiology and Medicine, UCLA School of Medicine, Los Angeles, California

Electromagnetic flowmeters were used to determine the effects of iproveratril on cardiac function and on blood flow in the femoral, renal and superior mesenteric arteries of cats anesthetized with pentobarbital. Iproveratril produced vasodilatation in the vascular beds of the small intestine and denervated hind limb but not of the kidney. The hypotensive effect of the agent could be wholly accounted for by peripheral vasodilatation in doses below 0.25 mg/kg. Large doses also reduced cardiac output. All effective doses produced bradycardia even after vagotomy and beta-adrenergic blockade produced by i.v. propranolol. Large doses of iproveratril blocked the chronotropic effects of i.v. isoproterenol but did not prevent the isoproterenol-induced increases of stroke volume and maximum aortic flow rate.

Submitted on May 17, 1967
Accepted on August 10, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.