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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 3, 386-393, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF ETHANOL AND PENTOBARBITAL ON RELEASE OF ACETYLCHOLINE FROM CEREBRAL CORTEX SLICES

H. Kalant 1 and W. Grose 1

1 Department of Pharmacology, University of Toronto, Toronto, Canada

Ethanol, 0.11 M, reduces reversibly the amount of acetylcholine released by slices of rat or guinea-pig cerebral cortex incubated in medium containing 5 mM K+; in 15 or 27 mM K+ the acetylcholine release is greater but ethanol has no detectable effect. Pentobarbital has a biphasic effect, low concentrations stimulating and high concentrations inhibiting acetylcholine release. Both the stimulatory and inhibitory effects of pentobarbital are increased by raising the K+ concentration of the medium. In 15 mM K+, ethanol has no effect by itself but enhances the stimulatory effect of 0.01 mM pentobarbital. Brain slices from animals made tolerant to ethanol, by daily administration of intoxicating doses, are refractory to the in vitro effect of ethanol on acetylcholine release.

Submitted on May 8, 1967
Accepted on August 3, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.