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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 2, 279-285, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF CHOLINERGIC DRUGS ON PASSIVE AVOIDANCE IN THE MOUSE

S. L. Dilts 1 and C. A. Berry 1

1 Department of Pharmacology, Northwestern University Medical School, Chicago, Illinois

The effect in mice of each of several types of cholinergic drugs upon the " one-trial" acquisition of a passive avoidance response has been measured by a later retention test. When administered shortly before the first trial, scopolamine hydrobromide, atropine sulfate, physostigmine salicylate and mecamylamine hydrochloride produced a significant reduction in one-trial learning. A similar reduction in performance was not observed when the drugs were administered immediately after the first trial. Negative results obtained with corresponding quaternary drug derivatives indicate that the peripheral effects of the drugs examined do not contribute materially to the test results.

Submitted on November 19, 1965
Accepted on June 30, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.