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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 2, 272-278, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF AMPHETAMINES ON EATING ELICITED BY HYPOTHALAMIC STIMULATION

Paul Stark 1 and C. Wayne Totty 1

1 The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

Rats were prepared with chronically implanted electrodes in the lateral hypothalamus. The current intensity necessary to elicit eating by these animals, after they had been freely fed, was measured. Five clinically useful appetite-suppressant drugs, amphetamine, methamphetamine, diethyl propion, pheninetrazine anti chlorpbentermine, were administered i.p. to these animals at several dose levels. All of the drugs increased the current intensity necessary to elicit eating in these animals after they were freely fed. The effect, and in most cases the duration of effect, was direetly related to the drug dosage. Saline and 5 mg/kg of phenobarbital were without effect ; phenobarbital. 20 and 40 mg/kg, lowered the threshold to elicit eating, suggesting a specificity of action for the drugs studied.

Submitted on March 14, 1967
Accepted on June 23, 1967




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B. D. Berger, C. D. Wise, and L. Stein
Norepinephrine: Reversal of Anorexia in Rats with Lateral Hypothalamic Damage
Science, April 16, 1971; 172(3980): 281 - 284.
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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.